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Drug-Induced Liver Toxicity
Drugs sometimes cause serious injuries to the livers of patients, with loss of hepatic function leading to illness, disability, hospitalization, and even life threatening liver failure and death or need for liver transplantation. As our aging world population uses more and more drugs, as well as self-prescribed over-the-counter medications, so-called “dietary supplements,” special diets, alcohol, and is exposed also to environmental chemicals, chances of such injury are rising. In the United States, drug-induced liver injury (DILI) is now the leading cause of acute liver failure (ALF), exceeding all other causes combined [see below: recent graphic data from WM Lee and colleagues from the Acute Liver Failure Study Group, updated to include data through October 2009]:
This website is intended to present up-to-date presentations and discussions on issues pertinent to DILI, as well as some background information from previous conferences. The site is sponsored by the Food and Drug Administration’s (FDA) Center for Drug Evaluation and Research (CDER), together with the American Association for the Study of Liver Diseases1 (AASLD), the Drug-Induced Liver Injury Network2 (DILIN) of the National Institute of Diabetes and Digestive and Kidney Diseases3 (NIDDK), and Pharmaceutical Research and Manufacturers of America (PhRMA).
If you wish to use any of the material posted at this website, please request permission from any of the authors4 to do so, and please cite the source of the material giving credit to them.
Please send critique, comment, and suggestions for improvement of this website to John R. Senior, M.D. (john.senior@fda.hhs.gov) or Lana Pauls, M.P.H. (lana.pauls@fda.hhs.gov).
2010 Meeting
The 2010 meeting will be held on March 24-25 at the National Labor College in Silver Spring, Maryland.
To register, please go to the AASLD meeting registration6 web site.
Previous Meetings
- AASLD-FDA-NIH-PhRMA- Hepatotoxicity Special Interest Group Conference7, 2009
- AASLD-FDA-NIH-PhRMA- Hepatotoxicity Special Interest Group Conference8, 2008
- AASLD-FDA-NIH-PhRMA- Hepatotoxicity Special Interest Group Conference9, 2007
- AASLD-FDA-NIH-PhRMA- Hepatotoxicity Steering Group Meeting10, 2006
- FDA-PhRMA-AASLD Hepatotoxicity Steering Committee Meeting11, 2005
- Hepatotoxicity Steering Group Meeting12, 2004
- Hepatocoxicity Steering Group Meeting13, 2003
- Drug-Induced Liver Injury: A National and Global Problem14, 2001
- Drug-Induced Liver Injury: Mechanisms and Test Systems. NIH Conference at Lister Hill Center, October 17-18, 2000 (summarized in: Hepatology 2001 Apr;33(4):1009-13)
- CDER Staff College Course: Drugs and the Liver: What They Do to Each Other. April 19-20, 1999. Course agenda (PDF - 82KB)15
Report serious adverse events to FDA's MedWatch at 1-800-FDA-1088; or go to MedWatch: How to Report16