 Causes of Stevens Johnson Syndrome
/ Toxic Epidermal Necrolysis
 Drugs cause over 80% of all cases of SJS / TEN. However, 90-95% of TEN cases are caused only by medications. While there have been very rare reports of infections causing SJS and TEN, most of those case reports were published long before scalded skin syndrome and TEN were distinguished by biopsy, making these cases more likely to have been caused by a drug. The rarity of these reports cast doubt on the reliability of information taken regarding drug intake, and doesn't change the fact that almost all cases of TEN are always caused by a single drug. NSAIDs have recently been recognized by the scientific community to be one of the leading causes of SJS and TEN. A recently published study reported significantly increased risk for ibuprofen in an epidemiologic study published in 2003. (Mockenhaupt, et. al. 2003; Lesko, et. al. 1995.) Anti convulsants and antibiotics are the other leading causes of these diseases. There is also some evidence to support that pre-existing infections coupled with the ingestion of one of these drugs mentioned above causes a synergistic effect that leads to SJS and TEN, including antibiotics and OTC medications like Children's Advil and Children's Motrin. |